Does Menopause Hit Like a Cliff? What a New Global Study Found

A new study just analysed 300 million lab results from over a million women and concluded menopause doesn't ease in, it drops. Australian menopause experts aren't convinced it's that dramatic, but here's what the data actually shows, and why the shape of the curve matters less than what's happening underneath it.

The study behind the headline

The research, published in Nature Medicine analysed more than 300 million laboratory tests from over a million women in the US and Israel, tracked between 1999 and 2024. The team found abrupt, step-like changes across nearly every system they measured: sex hormones, bone health, liver and kidney function, blood chemistry and blood fats. Accelerated change seemed to begin around 15 years before menopause, roughly seven years earlier than the long-running SWAN study had previously suggested. Women taking menopausal hormone therapy showed smaller sudden shifts, particularly for bone, liver and kidney markers, which led Alon to suggest bone density checks around age 40 to 45, with hormone therapy considered as prevention on a doctor's advice.

Australian experts are calling it overdramatic

Professor Martha Hickey of the Women's Hospital Victoria, who wasn't involved in the study, called the cliff framing unnecessarily alarming and pointed out that a physiological cliff isn't actually a scientific or medical term. Elina Safro from the Australasian Menopause Society went further, saying the cliff theory isn't plausible. The core objection is about method, not just vibes. This study looked backwards at existing data and relied on women's own memory of their last period, while SWAN was designed from the start to follow women forward in time. SWAN's data points to gradual change over about three years, not a sudden drop. Hickey also noted there's no solid evidence hormone therapy prevents heart disease or dementia, and that healthier women may simply be more likely to use it in the first place, which can skew comparisons. All four experts quoted agreed on one thing: more research is needed before anyone declares the shape of the curve settled.

Cliff or slope, your body's still doing something

Whatever the final verdict on cliffs versus slopes, hormonal shifts around this stage of life are real, and plenty of women notice changes in skin sensitivity and sweat patterns somewhere in the mix, cliff-shaped or not. University of Melbourne endocrinologist Ada Cheung's advice is the sensible middle ground here: get your bone density, cholesterol, blood pressure and blood sugar checked in your 40s, and have the conversation with your GP regardless of which study wins the argument. If your skin's started reacting differently to things it used to shrug off, this is worth a read on natural deodorant for reactive skin. And if the whole-body sweat conversation has found its way into your group chat, we've already covered whether you actually need a whole-body deodorant.

Source: Is there a 'cliff-like' decline at menopause? Australian experts unconvinced, ABC News, published 13 October 2026.

Scientists are still arguing about whether it's a cliff or a slope. Either way, somewhere in your 40s your body quietly changes its settings without so much as a memo. We'll just keep paying attention to what shows up on the other side.